This combination of meds had the remarkable result of shrinking my very large tumor by a full 50 percent! - currently getting pumped of the lovely docetaxel! Furthermore, the overall response rate for docetaxel in the intent-to-treat population (42.5%) is superior to the response rate of either doxorubicin as second-line therapy . Prostate cancer is the most frequently diagnosed cancer in men; an estimated 192 280 new cases and 27 360 deaths of prostate cancer will occur in the US during 2009.1 However, approximately 22% of cases will be diagnosed with advanced or metastatic disease, with an additional 25% developing metastases throughout the course of the disease. For instance, they may continue to work, spend time with family, and exercise. If you feel unwell or have any of these signs, tell them straight away. All patients should be premedicated with oral corticosteroids (see below for prostate cancer) such as dexamethasone 16 mg per day (e.g., 8 mg twice daily) for 3 days starting 1 day prior to TAXOTERE administration in order to reduce the incidence and severity of fluid retention as well as the severity of hypersensitivity reactions [see Boxed Warning, Warnings and . Use of this online service is subject to the disclaimer and the terms and conditions. You will be given a corticosteroid prior to the infusion to prevent severe fluid retention and allergic reactions. Men initially treated with Taxotere had favorable outcomes compared to those who were initially treated with Novantrone: Median overall survival was 22 months for men treated with Taxotere first and 15 months for those treated with Novantrone first. Tax is bad, next time compounded it might be worse, roll on July! The steroid is given in pill form or by IV, which will be determined by your healthcare provider. I'd go around 10 days of feeling ****, nausea, constipation, diarrhea, mouth sores, joint pains, metallic taste in mouth; I hated it! Humor can also lessen anxiety and discomfort, allowing cancer patients to talk more openly about their concerns and fears. Copyright @ 2019 binews.org | All Right Reserved. I ended up in hospital 4 days after treatment.. A swift and successful op was followed by FEC-T chemo. Nicole B. Youre coming back off. I had my first T part last Thursday and I to have struggled with severe tiredness but worst is the pains in my legs and arms. I have a good support system at home who do just about everything as I have been bed or sofa bound for the last 10 days with just small walks around the house to keep the circulation going. You may also experience difficulty breathing, joint stiffness, pain, and even behavioral changes. Many women who receive taxane -based chemotherapy to treat breast cancer experience long-term peripheral neuropathy, according to follow-up data from a large clinical trial. Try to eat five or six small meals or snacks throughout the day, instead of 3 larger meals. A baking soda and/or salt with warm water mouth rinse (2 level teaspoons of baking soda or 1 level teaspoon of salt in an eight ounce glass of warm water) is recommended 4 times daily. For cycle 2 I used a great mouthwash - Difflam and have had no sore mouth problems since. I think it would have been better to know just what to expect but as we all react different it's not possible. Except she would always end up in hospital as her temp would spike along with the joint pains. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. I've had all three FEC sessions and coped really well and was positive and active. Not easy at all. I turned 52 just a few days after that first Taxotere Chemo treatment. Ask your oncology care team about nutritional counseling services at your treatment center to help with food choices. Dragged myself to picc line clean at hospitalbad mistake, will have district nurse call next time. Call your oncology care team if you are unable to keep fluids down for more than 12 hours or if you feel lightheaded or dizzy at any time. Signs of a reaction can include: feeling hot or flushed shivering itching a skin rash feeling dizzy a headache feeling breathless or wheezy swelling of your face or mouth pain in your back, tummy or chest. A post shared by Soulcake (@soulcake) on Jul 18, 2017 at 9:40pm PDT. So would recommend this. It is not a substitute for professional medical advice. It really helps to have these words of encouragement and support. While it sounds harmless enough, constantly tearing eyes can cause other health issues. Get the B**tard out for good! Keep going with strength and positive thinking and hopefully you will see improvement in your circumstances. Your doctor may prescribe medication to take before your treatment to help decrease the risk of edema. Been told its best to as it helps the operation be morebsuccessful. some were bad and some were tolerable plus i also had insomnia because of the steriods.Tell Donna to hang in thereand good luck to you Bob! Perseverance!! If docetaxel does not work or stops working, cabazitaxel (Jevtana) may . Copyright 2000-2022 Cancer Survivors Network. Treatment . I have been given so many tablets with this cycle which need to be taken with food but find eating almost impossible due to chemo mouth explosion of thrush despite being on medication. Your healthcare provider can recommend medications and other strategies to help relieve pain. Hi. Will try the mouthwash as that is also a problem, I have a drink and seconds later my mouth is so dry again! I was on taxotere, carboplatin, and Herceptin every 3 weeks. I had the FEC-T chemo first, from December 2013 to April 2014. It is a combination of two chemotherapy medicines: Docetaxel (Taxotere) Cyclophosphamide (Cytoxan) Docetaxel is a type of chemotherapy medicine called an taxane. Severe symptoms are less common but require dose modifications. By the second cycle,my nausea would start as Im getting my infusion. I spent yesterday in A&E with chest pains which turned out to be heartburn and anxiety. Don't plan your chemo response until you've gone through your first infusion. Even if your menstrual cycle stops or you believe you are not producing sperm, you could still be fertile and conceive. Take care and we will get through this. Thank you, hope you continue to be well. While receiving treatment, your WBC count can drop, putting you at a higher risk of getting an infection. I took nausea tabs even when I wasn't nausaus, but it made little difference. i have been lucky to have good support but the weakness in my legs and arms and neck, have been bad and still are two weeks later I feel my body just wants to colapse when I get to the sink to try to do the dishes, so I have to sit down and wait until I feel better. So got it again. I don't want to put anyone off this treatment as I know it works wonders on the tumour , we all react differently as previously advised on here, but I want understand where I went wrong and what I can do to prepare myself for the next cycle. constipation. It won't be long until you to are in a position to help others with your experiences of the journey we all find ourselves on. Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. Your physician will order lab tests throughout your treatment to keep an eye on your levels. So into hospital she went each time. Peripheral neuropathy is a toxicity that affects the nerves. When thered cell count is low, you may feel tired or weak. Hope you are well now too. Drugmakers developed it from the bark of the Pacific Yew tree, and researchers sometimes refer to it as a plant alkaloid. Please. Will be glad to see you here soon Post Chemo, looking forward to your break away with your husband. None worked. After starting docetaxel, many men experience the improvements in disease-related symptoms, including pain, fatigue and loss of energy. Taxotere injections can cause serious and life-threatening fluid retention(edema). If you experience nausea, lack of appetite, or other eating problems, discuss solutions with your doctor or nurse navigator. I think the medications have caused some of the issues but I long to enjoy the taste of nice food. Hope you are all doing well with your journey and keeping well. It is so much easier than the taxotere, virtually no side effects at all. Edema happens when fluid collects under your skin and within the tissues outside your circulatory system. At that time, TAXOTERE was typically used for advanced prostate cancer, after all other treatments had failed. One of the common types of chemotherapies for breast cancer, AC + T includes three drugs: doxorubicin (Adriamycin), cyclophosphamide (Cytoxan), and a taxane drug (Taxol, Taxotere . On Taxol I was comnpletely exhausted on days 2 - 6 and napping/resting did not help at all. . worst daysfor me it was the week after the infusion..I just fall apart.tired, ache, intestinal issuesetc. And a bit of movement / chatting / getting out of the house helps.. Keeping positive and looking forward to getting to the end of it all. Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. The cycles were repeated every 3 weeks for 3 . July 16, 2018. Hard to rest with all the side effects of all the drugs but I did my best. A week later, I would have another dose of Gemcitabine and an hour of Taxotere. I was on taxotere and idI was on taxotere and id have my treatments on monday, and wednesday & thursdays were my bad days. The interval between each treatment gives your body time to recover. Even my vision has been effected. We can do itnot sure how but we are two thirds there. Anyway, like you im a very positive person, was dealing very well with it all, had 3 rounds of EC first.. Now two rounds left of Docetaxal.. Im floored.. I was tired and took naps on my days off. Anemia, or a shortage of red blood cells, can make you very tired. It wasnt until the following year that food started to taste good again. We have each other even if we don't know each other. We started working from home the week after the infusion. Yes, this is much tougher than the FEC but it really is worth it x, Thank you biddenden_ sue knowing that others have had the same experience make me accept mine better. My own experience to date As of day 8 after my first Tax blast, I currently hate Tax and FEC in equal measure. Weirdly, her pain would only come on around 3pm-6pm, then her temp would spike like crazy too. Give yourself credit for getting this far. They had no idea, and still have no idea why her body was reacting the way it was. I got off lightly on the 4 AC, only had a couple of very bad days each cycle. Please assign a menu to the primary menu location under MENU. So would recommend this. Each mL contains 40 mg docetaxel (anhydrous) and 1040 mg polysorbate 80. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling . I am trying to keep focused and positive to get through this. Really sorry to read that you having such a s---- time with your current chemo treatment. This can get progressively worse with additional doses of the medication. Sun sensitivity can last even after chemotherapy is completed. It has now been almost exactly 4 days (96 hours) since. I am just unfortunate to get them all. You may notice dry skin or changes in the color or tone of your skin. While it sounds harmless enough, constantly tearing eyes can cause other health issues. Taxotere (docetaxel) is a chemotherapy drug used to treat a variety of cancer types including non-small cell lung cancer, prostate cancer, breast cancer, stomach cancer, and head and neck cancer. To view profiles and participate in discussions please. So I queried the need for the remaining 2 docetaxel. Your labs will be closely monitored prior to each dose of docetaxel and the dose may be decreased or held if your liver function is not normal. We've heard that the Taxol is a lot easier. My doctor did reduce the docetaxen for me after the first one e and it made a difference, My advise is phone your doctor or key worker and ask if them if they can reduce the doseage. I think I am coming to the end of feeling like I have hit by a bus with the chronic aches in all my joints and bones. Did they check your bloods in A&E?? Last night she was saying that she doesn't know how she is going to get through the next treatment, especially since they supposedly get worse each time. You will have got through it now though? Each course of chemotherapy lasts for 8 weeks. ), and have smoked and used alcohol for most of my life. You don't sound negative, you just sound disheartened that after following all advice you are still suffering and also that you are finding treatment difficult. Sorry to be such a negative misery , I am usually upbeat and positive but wanted to ask if these cycles compound with the side effects as I am not sure I could cope with another 2 cycles. I'll be starting this Thursday and have 10 steroids to take Wednesday night and then whatever they give me as pre-meds. TAXOTERE is sterile, non-pyrogenic, and is available in single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous). I did everything I could. You may experience a metallic taste or find that food has no taste at all. Other effects for me are tingling in feet, skin peeling off, mostly in feet, toe nails highly sensitive. We are all stronger than we think and even stronger than we give ourselves credit for! But I'm on SSP and we can't afford to have him stay at home every time I feel ****. It may get worse after you have your last chemotherapy treatment. Hi, As long as I moved and tried to do those things, even though I felt crappy, I would always feel better afterwards. She keeps telling me that she is not strong enough to do this; and I tell her that she is stronger than she thinks she is.Bob. When meds say 'Take with food' a couple of biscuits or something similar is enough. The infusion will be slowed or stopped if this occurs. After that, I have been okay - really tired and nothing tastes good so I am not eating well - but I learned from my first course of chemo that ended in April that I need to sleep when I am tired, so sometimes when I get home from work, I go right to sleep. and Friday, Donna did too much on Saturday, taking my daughter to the mall; shopping for most of the day. for use in the treatment of prostate cancer in the year 2004. Please consult with your healthcare team regarding the use of these agents and all over the counter medications/supplements while on therapy. Taxotere Side Effects If you or a loved one want to prepare and learn about the worst days on Taxotere, many patients often receive Taxotere in combination with other chemo drugs. Platelets help your blood clot, so when the count is low you are at a higher risk of bleeding. Docetaxel interferes with the function of microtubules, resulting in inactive microtubule bundles, causing cells to die. Yes you will have have to have the G - CSFinjections for the bone marrow stimulation after the Docetaxal chemotherapy - the same as the FEC. APAP vs. CPAP: Whats the Best Machine for Sleep Apnea? I know everyone is different. It's horrid and depressing. There is a risk that this medication may leak out of the vein at the injection site, resulting in tissue damage that can be severe. And it may even boost our immune systems. This study found that women diagnosed with hormone-receptor-positive breast cancer did benefit from getting a taxane. Days 1,8: Gemcitabine 900mg/m 2 IV at a rate of 10mg/m 2 /minute, followed by: Day 8: Docetaxel 75-100mg/m 2 IV over 1 hour. I have to agree, as much as I dont want to get off the couch.. The month of October 2008 was one of the worst in New York Stock Exchange history, with three of the top 10 largest single-day drops ever recorded during the month. Taxotere is a chemotherapy drug made by Sanofi-Aventis. Wear sunscreen (at least SPF 15) every day, wear sunglasses and long sleeves/pants to protect your skin. Best wishes to everyone on this treatment and you will come out the other side. Its normal to feel completely wiped out when you begin this medication. Brady appears to be expanding his brand rapidly in 2023. Can I just say thank you so much for the great advise, I am going through Taxotere part of chemo at the moment and it is just horrible, my poor hands are the worst, they are burning like mad but have been prescribed Piriton and paracetamol to try and rectify overnight and have to go to hospital in the morning that does seem to have helped. What Is the Taxotere Mechanism of Action? An analysis of several studies found that chemotherapy regimens that include an anthracycline are better than a regimen that doesn't include an anthracycline for women diagnosed with early-stage, HER2-negative breast cancer with a high risk of recurrence. However on week 3 of the cycle got more or less back to normal before the next onslaught. MYTH #6: I'll permanently lose all my hair after chemo. Keep reading our blogs for morehealth blogs to help you live a healthy life. Fatigue. If you are not eating enough, nutritional supplements may help. I feel disappointed in myself for being negative as I have tried to see the bigger picture and my goal but have felt so exhausted and low. Ps Voltarol Gel is good rubbed in for the lower back pain. Bored with food, inspite of adding fruit after my steroid sugar ban. Do not take aspirin (salicylic acid), non-steroidal, anti-inflammatory medications (NSAIDs) such as Motrin/Advil (ibuprofen), Aleve (naproxen), Celebrex (celecoxib), etc. Im not an athlete by any means, but I could swim and I could walk. The problem some people run into with Taxotere is that the hair loss can sometimes be permanent. I feel more at ease in this second week of treatment and hope to have recovered enough to have my next cycle. We think its important to know what you might expect on your worst days on Taxotere. Researchers spent YEARS finding chemotherapy compounds that could attack prostate cancer cells. You will have docetaxel as an outpatient. Plan times to rest during the day and conserve energy for more important activities. The physical act of laughing produces endorphins that help to alleviate pain. If we can get through this we can face anything. Thanks everyone for your messages of support. But it was worth it when looking at the larger picture. Good luck , The first dose of docetaxol was the worst for me. I had 4 months neojuvent you all, besides the sea swimming, crafting, reading and writing poetry, I have taken up cycling result of the biopsy by the end of this week. I have severe bloating which is so uncomfortable its almost painful. Dragged myself to picc line clean at hospital.bad mistake, will have district nurse call next time. Soluble fiber is found in some foods and absorbs fluid, which can help relieve diarrhea. I lost my hair and everything, but the chemo itself was not that bad. It takes the edge off the pain which means taking paracetamol with it actually works. You should let the oncology care team know if you experience numbness or tingling in the hands and/or feet, as they may need to adjust the doses of your medication. And yes, for me at least, it is cumulative and is a bit worse each cycle. Talk to your oncology care team so they can prescribe medications to help you manage nausea and vomiting. Cyclophosphamide is a type of chemotherapy medicine . Eyes watery but ok. If the count gets too low, you may receive a blood transfusion. Patients may struggle with never-ending itchiness, swollen eyelids, and an increase in floaters. They might also encounter infections and inflammatory disorders as a result. I do have to rest far more than I used to, although I manage to cope with a busy full time job. Had the FEC-T chemo work, spend time with family, and have no... May receive a blood transfusion other eating problems, discuss solutions with your husband outside your system! Used a great mouthwash - Difflam and have had no idea why her body was reacting way... Before your treatment center to help decrease the risk of edema Gel is good in... Openly about their concerns and fears was not that bad the edge off the couch the onslaught! Mouth is so uncomfortable its almost painful after chemotherapy is completed it made little difference encouragement support. 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Oncology care team about nutritional counseling services at your treatment to help you manage nausea and.. Cope with a busy full time job hopefully you will see improvement in circumstances! Having such a s -- -- time with your doctor or nurse navigator remaining 2 docetaxel everything but. I am trying to keep focused and positive thinking and hopefully you will be slowed or stopped if occurs. Use in the color or tone of your skin * * * thinking and you! And conditions when meds say 'Take with food, inspite of adding fruit my. I took nausea tabs even when I was n't nausaus, but I to... They can prescribe medications to help relieve diarrhea spent YEARS finding chemotherapy compounds that could attack prostate,... You continue to be well all three FEC sessions and coped really well and positive... Are tingling in feet, toe nails highly sensitive two thirds there toxicity affects. The improvements in disease-related symptoms, including pain, and Herceptin every 3 weeks 3. 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Her body was reacting the way it was worth it when looking at the larger picture snacks the., they may continue to work, spend time with family, and.!
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